What can result from withdrawal of tricyclic antidepressants?

Withdrawal from tricyclic antidepressants is known to cause a rebound increase in REM sleep. Tricyclic antidepressants typically suppress REM sleep during the period of use, as one of their pharmacological effects is to reduce the overall time spent in this sleep stage. When these medications are withdrawn, the suppression is lifted, leading to a rebound effect where REM sleep not only returns but may also increase beyond normal levels. This can result in more vivid dreams or nightmares during the withdrawal period.

This rebound phenomenon highlights the body's response to having been adjusted to the presence of the medication, indicating an adaptive change to the sleep architecture while on the drug. Understanding this rebound effect is essential for sleep technologists and healthcare providers in managing patient care during the withdrawal phase.